Revolution in the skin microbiome
Microbiome Stimuli Base, is a raw material that affects the microbiome and is able to effectively help people suffering from psoriasis, eczema and atopic dermatitis (AD).
INCI:Bifidobacterium/(Lactobacillus/Saccharomyces/Schizosaccharomyces/Zygosaccharomyces Ferment Filtrate) Ferment Filtrate.
Mono ID (INCI): 38149
Stages of work
The need for introducing a new raw material.
The number of people suffering from psoriasis is 3% of the world's population, those with atopic dermatitis (AD) make up 1-3% of the world's population, while eczema affects 15-20% of the child population.
Currently, there is no product on the market that effectively regulates the skin microbiome of such individuals.
Solution!
Regulation of microorganism abundance on the skin's surface.
The action of the raw material - the mechanism of regulating the skin microbiome.
The skin microbiome plays an important role in maintaining skin health and balance.
The skin microbiome plays an important role in maintaining the health and balance of the skin.aOn the one hand, microorganisms prevent the growth of pathogens, or pathogenic microorganisms, which can cause inflammation, infections and other dermatological problems.
On the other hand, the skin microbiome influences the functioning of our immune system, and regulates processes related to sebum production and the maintenance of skin moisture.
The skin of people with psoriasis eczema and AD, has a pathological microbiome dominated by pathogenic species such as S.aureus.
MSB's raw material allows regulating the number of microorganisms on the skin's surface through competitive signaling that causes pathogens to reproduce more slowly.
Scheme of MSB
operation over time
The first product on the market that simultaneously:
Regulates the skin microbiome
Reduces the population of S.aureus
Environmentally friendly
Easy to transport and dose
Supports the reproduction of commensal bacteria
Research carried out before the raw material was introduced to the market
Pathogen inhibition levels - results for different concentrations.
Measurements of the maximum growth rate of microorganisms, specifically pathogenic cells, were conducted. Optical density (OD) measurements were taken at a wavelength of λ=600nm during exponential growth. Subsequently, the results for various concentrations of the raw material were compared to the control, and the percentage inhibition at different MSB concentrations was calculated. The results are presented in the table.
Assessment of cellular toxicity
Cellular toxicity assessment was performed using a fibroblast cell line (V79), which was exposed to various concentrations of the bioferment. Subsequently, cells were seeded onto special 96-well plates made of SBS material, allowing for real-time cell observation using the Nanolive 3D CX-A holographic microscope. Cell morphology images were obtained every 1 hour for the first 12 hours after the addition of MSB to their culture. Then, at 24, 48, and 72 hours. The results indicate the absence of cellular toxicity, as presented in the adjacent image.
Dermatological tests
Dermatological studies have demonstrated that MSB does not cause irritations on sensitive skin, both 48 hours and 72 hours after the application of 100% raw material.
The analyzed group was n=20.
Physicochemical properties of the raw material
Water-based product
Recommended concentration: 2-20%
Maximum allowable concentration: 30%
pH = 3.8-4.0
The pH range for optimal regulatory results: 3.5-8.
Stability at temperatures: 0-40°C
Storage stability: up to 6 months (unopened)
Possibility of preservation using dehydrooctanoic acid and benzyl alcohol, as well as sodium benzoate and potassium sorbate
Storage conditions: room temperature
Possibilities of using the raw material
Emulsions, including white creams, body lotions, hair lotion, face serum.
Cleansing products, including body gels and foams.
Deodorizing products, especially for roll-on and cream deodorants.
Benefits of using Microbiome Stimuli Base
Problem łuszczycy, egzemy i AZS jest powszechny, dlatego istnieje zapotrzebowanie na produkty przyczyniające się do redukcji widocznych skutków ich występowania. Obecnie żaden kosmetyk na rynku nie posiada właściwości, które skutecznie wpływałyby na regulację mikrobiomu skóry.
Reasonably priced raw material.
Undemanding storage conditions.
Large transport possibilities.
Possibility to reach a new market segment.
Raw material recognized as innovative by:
Dermatologists
Pharmacists
Innovator of Podkarpacie
Contact Us!
Do you have any questions? Our team will be happy to help you!
510 500 617
magda.biesiadecka@orcideo.pl
ada.frydrych@orcideo.pl
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